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Total synthesis of Aigialomycin D:
Reference: Calo, F.; Richardson, J.; Barrett, A. G. M. Org. Lett. 2009, 11, 4910. DOI
Keywords: Lactone → Lactol • Alkyl-OH → Aldehyde • CarboxEster → CarboxAcid • CarboxAcid → CarboxCl • Retro-Diels-Alder → Ketene • Ketene synthesis • Ketal → Diol-1,2 • Wittig-carboxymethyl → EnoateEster • Wittig-alkyl → Ene-cis • Claisen acylation, acyl-X • Decarboxylation • Ketene+Alcohol • RCM → Lactone • Benzene synthesis •
Reagents: AlHiBu2 • PPh3=CH-CO2R • Dess-Martin • PPh3=CH-Me • AlHiBu2 • PPh3=CH-CO2R • Hydroxide, lithium • Oxalyl chloride • MgCl2 • Pd(PPh3)4 • Acetate, cesium • Grubbs-Hoveyda • HCl • Grubbs-Hoveyda • Acetic acid •

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