image

Total synthesis of Agelastatin A:
Reference: Davis, F. A.; Deng J. Org. Lett. 2005, 7, 6218. DOI Davis, F. A.; Zhang, J.; Zhang, Y. Qiu, H. Syn. Commun. 2009, 39, 1914. DOI
Keywords: CarboxEster → CarboxAmide(Weinreb) • N-SO2R → N-H • CarboxAcid → CarboxEster • Sulfinamide, chiral • CarboxEster enolate+Imine • Imine+Enolate • N-Bn → N-H • Aryl-H → Aryl-Br • Urea • ConjAdd Amine • CarboxAmide(Weinreb)+Mg-R • Mg-Allyl+CarboxAmide • Alkene isomerization •
Reagents: Sulfinamide • LiN(OMe)Me • Acetic acid, trifluoro • Allyl-MgX • HBTU • Grubbs II • Carbonate, cesium • H2, Pd • Isocyanate • Bromohydantoin • NEt3

Syntheses Home