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Total synthesis of Aflatoxin M-1:
Reference: Buchi, G.; Weinreb, S. J. Am. Chem. Soc. 1969, 91, 5408-5409. DOI
Keywords: ArylO-H → ArylO-R • ArylO-Me → ArylO-H • O-Bn → O-H (phenol) • Ketone-α-Halo → Ketone-α-OR • Ketone+Mg-Alkyl • Mg-Allyl+Ketone • Alkene cleavage • Lemieux-Johnson oxidation • Aldehyde → Acetal • Acetate pyrolysis •
Reagents: Sulfate, dimethyl • Carbonate, potassium • AlCl3 • Benzyl-X • Carbonate, potassium • Tribromide, ammonium • Carbonate, calcium • Allyl-MgX • OsO4, NaIO4 • H2, Pd • Acetic anhydride • Flash vacuum pyrolysis • Bicarbonate, sodium • ZnCO3

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