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Total synthesis of Aflatoxin B-1:
Reference: Büchi, G.; Foulkes, D. M.; Kuromo, M.; Mitchell, G. F. J. Am. Chem. Soc. 1966, 88, 4534-4535. DOI
Keywords: O-Bn → O-H (phenol) • O-H → O-C(O)R (phenol) • Wittig-carboxymethyl → EnoateEster • Allylic oxidation → Enal • EnoateEster ConjReduct • Pechmann condensation • Friedel-Crafts Acylation, Ene • Lactone → Lactol • CompRed-Lactone/Ketone+B-H • Ester Pyrolysis •
Reagents: PPh3=CH-CO2R • SeO2 • Zn° • Acetic acid • Acetic anhydride • HCl, MeOH • HCl, H2O • Oxalyl chloride • AlCl3 • BH(Siam)2 • Acetic anhydride •

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