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Total synthesis of Acitretin:
Reference: Andriamialisoa, Z.; Valla, A.; Cartier, D.; Labia, R. Helv. Chim. Acta 2002, 85, 2926. DOI
Keywords: Aldehyde → Acetal(Me) • Acetal → Enal • CarboxEster → CarboxAcid • Claisen acylation, formate • Enone enolate+CarboxEster • Formate+Enolate • Stobbe condensation • Wittig-methyl → Diene • Decarboxylation •
Reagents: NaOMe • Formate, methyl • H2SO4 • KOtBu • PPh3=CH2 • Formic acid • Triton B • NEt3 • Hydroxide, sodium • Pyridine •

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