| Reference: | Comins, D. L.; Huand, S.; McArdle, C. L.; Ingalls, C. L. Org. Lett. 2001, 3, 469. |
| Keywords: | Lactam-5 --- H/Si -> Ene --- Alkyl-OH -> Ketone-α-OR --- Aldol-Li -> Enone --- Li-Alkynyl+Pyridinium --- Hydrogenation-Alkyne --- Lactam-5 --- O-C(O)R -> O-H --- Amine-5 --- CarboxAmide -> Amine --- Chelation control --- Li/H -> Li-Pyridyl --- Li-Pyridyl+Me-I --- Ketone -> Ketone-α-OH |
| Reagents: | MesLi --- MeI --- O=C(OR)Cl --- Alkynyl-Li --- H2, Pd --- LiOMe --- Pb(OAc)4 --- HCO2H --- BHsBu3-K+ --- DMSO, (COCl)2 --- LiCPh3 --- DBU --- BH(OAc)3-Me4N+ --- Propiolate --- TFAA --- AlH4-Li+ --- DMAP |