image

Total synthesis of Pederin:
Reference: Wu, F.; Green, M. F.; Floreancig, P. E. Angew. Chem. Int. Ed. 2011, 50, 1131-134. DOI
Keywords: O-SiEt3 → O-H • CarboxEster → Alkyl-OH • Aldol-B-Ipc • Ketone → Alkyl-OH • Ozonolysis • Aldehyde → Cyanohydrin • O-H → O-Me • Nitrile → Imine • Imine → Aminal •
Reagents: B(Cl)(Ipc)2 • BH4-Na+ • B(OMe)Et2 • O3 • PPh3 • Cyanide, trimethylsilyl • BiBr3 • BF3·OEt2 • MeOTf • Pyridine, 2,6-di-tBu • ZrCp2ClH • Mg(ClO4)2 • Fluoride, R4N+ • Hydroxide, lithium • Chiral auxiliary-Boronate •

Syntheses Home