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Total synthesis of Camptothecin:
Reference: Tang, C.; Rapoport, H. J. Am. Chem. Soc. 1972, 94, 8615
Keywords: Ketone -> Alkyl-OH --- O-C(O)OR -> O-H --- Alkyl-OH -> Ketone --- Allylic oxidation -> Allyl-OH --- Hoffmann elim -> Enoate --- Allylic oxidation -> Allyl-OH --- Claisen-Johnson --- Friedlander --- CarboxEster -> CarboxEster-α-OH
Reagents: BH4-Na+ --- Ac2O --- SeO2 --- AcOH --- Carbonate, potassium --- Carbodiimide --- SeO2 --- H2SO4 --- CuCl --- DMF (solvent) --- O2

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