Nancy H. Phillips -- PhD 1988

Scientific Career

Thesis Title Mechanistic Studies of the Lithium Metalloid Exchange Reaction.
Research Summary Nancy was the first serious organolithium chemist in the group. Her work was so productive, especially after the AM 360 NMR spectrometer arrived, that eventually this became a primary focus of the group. She established that iodine, tin and tellurium ate complexes were formed in THF and THF-HMPA solutions both by kinetic techniques, as well as by direct spectroscopic observation, and established these as likely intermediates in the lithium-metalloid exchange reaction.

As part of this work, Nancy first correctly established the nature of PhLi solutions (later studied more intensively by Pat Green, Biggie Gudmundsson, Marco Medina and Wayne Goldenberg, among others).

A major part of Nancy's work was devoted to the Li-Sn exchange reaction, where she characterized a series of previously unknown lithium pentaorganostannates, and did early experiments on the stereochemistry of the Li/Sn exchange at tin (later ably completed by Joe Borst and Mike Coplien). After her thesis work Nancy did post-doctoral work in Larry Miller's laboratory at the University of Minnesota before starting her job at 3M.

Papers
  1. "Lithium Metalloid Exchange Reactions. Kinetic Evidence for An Intermediate in the Lithium-Iodine Exchange," H. J. Reich, N. H. Phillips, and I. L. Reich, J. Am. Chem. Soc. 1985, 107, 4101. PDF

  2. "Lithium-Metalloid Exchange Reactions. Observation of Lithium Pentaalkyl/aryl Tin Ate Complexes," H. J. Reich and N. H. Phillips, J. Am. Chem. Soc. 1986, 108, 2102. PDF

  3. "Lithium Pentaalkyl/Aryl Tin Ate Complexes as Intermediates in the Lithium-Tin Exchange Reaction," H. J. Reich and N. H. Phillips, Pure Applied Chem., 1987, 59, 1021-1026.

  4. "The Lithium-Metalloid Exchange. Dynamics and Equilibrium in the Li/I and Li/Te Exchange in Tetrahydrofuran: Iodine Tellurium and Mercury Ate Complexes," H. J. Reich, D. P. Green and N. H. Phillips, J. Am. Chem. Soc. 1991, 113, 1414. (Communication) PDFl

  5. "Mechanism of the Lithium-Tellurium, Lithium Iodine and Lithium-Mercury Exchange Reactions: Hypervalent Tellurium and Iodine Ate Complexes," H. J. Reich, D. P. Green, N. H. Phillips and J. P. Borst, Phosphorus, Sulfur, Silicon, 1992, 67, 83. (Article) PDF

  6. "The Lithium-Tin Exchange Reaction. Stereochemistry at Tin," H. J. Reich, J. P. Borst, M. B. Coplien and N. H. Phillips. J. Am. Chem. Soc. 1992, 114, 6577. (Communication). PDF

  7. "Aggregation and Reactivity of Phenyllithium Solutions," Hans J. Reich, D. Patrick Green, Marco A. Medina, Wayne S. Goldenberg, Birgir Ö. Gudmundsson, Robert R. Dykstra, and Nancy H. Phillips, J. Am. Chem. Soc. 1998, 120, 7201-7210. (Article) PDF Suppl.

Current Position Renewable Energy Division, 3M Company
3M Company

Nancy and Craig on the Kickapoo


For comments, additions and corrections, send e-mail to Hans J. Reich