Richard E. Olson -- PhD 1982

Scientific Career

Thesis Title Rearrangements of Propargyl Selenoxides. Siloxyallyl- and Allenyllithium Reagents from Acyl Silanes.
Research Summary Rick worked on several projects in the silyl ketone area, most notably the synthesis of allenyl silyl ethers by the addition of lithium acetylides to acyl silanes followed by alkylation of the allenyllithium reagent formed by Brook rearrangement.

Papers
  1. "Silyl Ketone Chemistry. A New Regiospecific Route to Silyl Enol Ethers," H. J. Reich, J. J. Rusek and R. E. Olson, J. Am. Chem. Soc. 1979, 101, 2225. PDF

  2. "Silyl Ketone Chemistry. Preparation of Siloxy Allenyl- and Allyllithium Reagents," H. J. Reich, R. E. Olson and M. C. Clark, J. Am. Chem. Soc. 1980, 102, 1423.

  3. "Selenium Stabilized Anions. Preparation of alpha,beta-Unsaturated Carbonyl Compounds Using Propargyl Selenides. Synthesis of (+)-7-Hydroxymyoporone," H. J. Reich, S. K. Shah, P. M. Gold and R. E. Olson, J. Am. Chem. Soc. 1981, 103, 3112. PDF

  4. "Silyl Ketone Chemistry. Preparation and Reactions of Unsaturated Silyl Ketones," H. J. Reich, M. J. Kelly, R. E. Olson and R. C. Holtan, Tetrahedron 1983, 39, 949. PDF

  5. "Silyl Ketone Chemistry. Preparation and Reactions of Silyl Allenol Ethers. Diels-Alder Reaction of Siloxy Vinylallenes Leading to Sesquiterpenes," H. J. Reich, E. K. Eisenhart, R. E. Olson, and M. J. Kelly, J. Am. Chem. Soc. 1986, 108, 7791. PDF

  6. "Preparation of 3-Substituted-4-methyl Furans: 3-Iodo-4-methyl- and 3-Formyl-4-methyl Furan," H. J. Reich and R. E. Olson, J. Org. Chem. 1987, 52, 2315.

Current Position Associate Director, Chemical and Physical Sciences (drug discovery in neuroscience.)
DuPont Pharmaceuticals


For comments, additions and corrections, send e-mail to Hans J. Reich