Martha J. Kelly -- PhD 1983

Scientific Career

Thesis Title Synthesis and Reactions of α,β -Unsaturated Silyl Ketones.
Research Summary Martha developed the synthesis of a series of interesting previously unknown types of unsaturated silyl ketones. She used the chemistry allenol ethers, which was also being developed by Rick Olson and later by Ron Holtan and Mike Bowe.

These compounds could be used in the various applications of the Brook rearrangement which were the focus of this work. The synthesis of vinyl allenes developed by Martha was later used very effectively by Eric Eisenhart in sesquiterpene synthesis using intramolecular Diels-Alder reactions.

After finishing her thesis work at Wisconsin Martha did a post-doc in Oppolzer's laboratory in Geneva, Switzerland.
Papers
  1. "Silyl Ketone Chemistry. Synthesis and Reactions of Olefinic and Acetylenic Silyl Ketones," H. J. Reich and M. J. Kelly, J. Am. Chem. Soc. 1982, 104, 1119.

  2. "Silyl Ketone Chemistry. Preparation and Reactions of Unsaturated Silyl Ketones," H. J. Reich, M. J. Kelly, R. E. Olson and R. C. Holtan, Tetrahedron 1983, 39, 949.PDF

  3. "Silyl Ketone Chemistry. Preparation and Reactions of Silyl Allenol Ethers. Diels-Alder Reaction of Siloxy Vinylallenes Leading to Sesquiterpenes," H. J. Reich, E. K. Eisenhart, R. E. Olson, and M. J. Kelly, J. Am. Chem. Soc. 1986, 108, 7791.PDF

  4. "Stereochemistry of Vinylallene Cycloadditions," H. J. Reich, E. K. Eisenhart, W. L. Whipple and M. J. Kelly, J. Am. Chem. Soc. 1988, 110, 6432. (Article)

Current Position Senior Director,Research and Compound Development
Madrigal Pharmaceuticals

Martha at poster session in 1981


For comments, additions and corrections, send e-mail to Hans J. Reich