Ronald C. Holtan -- PhD 1984

Scientific Career

Thesis Title Stereocontrolled Synthesis of Silyl Enol Ethers Using α-Phenylthio Silyl Ketones.
Research Summary Ron developed synthetic methodology for highly streoselective synthesis of enol ethers using the reaction of α-substituted silyl ketones (acyl silanes) with nucleophiles.

Papers "Silyl Ketone Chemistry. Preparation and Reactions of Unsaturated Silyl Ketones," H. J. Reich, M. J. Kelly, R. E. Olson and R. C. Holtan, Tetrahedron 1983, 39, 949.PDF

"Silyl Ketone Chemistry. Synthesis of Regio- and Stereochemically Pure Enol Silyl Ethers Using alpha-Phenylthio Silyl Ketones," H. J. Reich, R. C. Holtan and S. I. Borkowsky, J. Org. Chem. 1987, 52, 312. PDF

"Acylsilane Chemistry. Synthesis of Regio and Stereoisomerically Defined Enol Silyl Ethers Using Silyl Ketones," H. J. Reich, R. C. Holtan and C. Bolm, J. Am. Chem. Soc. 1990, 112, 5609. (Article)

Current Position Ellesworth Community College

Ron and family in 1981

For comments, additions and corrections, send e-mail to Hans J. Reich