Robert Edmonston -- MS 1999

Scientific Career

Thesis Title An Investigation into the Role of Lithium Catalysis on the Regioselectivity of Addition to , α,β -Unsaturated Ketones. I. Regioselectivity of cisoid Enone Addition. II. Kinetics of Bis(3,5-bis(trifluoromethyl)phenylthio)methyllithium. III. Regioselectivity of α -Lithiated Nitriles to Enones.
Research Summary Bob followed up on Bill Sikorski's work on the effect of HMPA on the regioselectivity of addition of lithium reagents to enones. He performed some very nice (and very difficult) kinetic work which showed clearly the strong rate-retarding effect of HMPA on the addition of metalated sulfides to cyclohexenone and other enones.

Papers "Reaction of Metalated Nitriles with Enones," Hans J. Reich, Margaret M. Biddle and Robert J. Edmonston J. Org. Chem. 2005, 70, 3375-3382. (Full Paper) PDF Suppl.

For comments, additions and corrections, send e-mail to Hans J. Reich