Margaret M. Biddle -- PhD 2005

Scientific Career

Thesis Title
I. Reaction of Lithiated Nitriles with Enones II. Studies on the Reactive Species in Fluoride-Mediated Carbon-Carbon Bond Forming Reactions III. Fluoride Sources
Research Summary Mechanism of Conjugate Addition of Enolates to α,β-Unsaturated Carbonyl Compounds. Intermediates in the Fluoride catalyzed reactions of Silanes
  1. "Reaction of Metalated Nitriles with Enones," Hans J. Reich,* Margaret M. Biddle and Robert J. Edmonston J. Org. Chem. 2005, 70, 3375-3382. (Article) PDF, Suppl

  2. "Studies on the Reactive Species in Fluoride-Mediated Carbon-Carbon Bond-Forming Reactions: Carbanion Formation by Desilylation with Fluoride and Enolates," Margaret M. Biddle and Hans J. Reich, J. Org. Chem. 2006, 71, 4031-4039. (Article) PDFSuppl, JOC Cover

  3. "Solution Structures of Lithium Enolates of Cyclopentanone, Cyclohexanone, Acetophenones, and Benzyl Ketones. Triple Ions and Higher Lithiate Complexes," Kristopher J. Kolonko, Margaret M. Biddle, Ilia A. Guzei, Hans J. Reich J. Am. Chem. Soc. 2009, 131, 11525-11536 (Article) PDF, Suppl, DOI

Current Position Medicinal chemist at Astellas Pharmaceuticals, Skokie, Illinois

Margaret having a good time in lab, 2002

For comments, additions and corrections, send e-mail to Hans J. Reich