Scientific Career

Thesis Title	I. Reaction of Lithiated Nitriles with Enones II. Studies on the Reactive Species in Fluoride-Mediated Carbon-Carbon Bond Forming Reactions III. Fluoride Sources
Research Summary	Mechanism of Conjugate Addition of Enolates to α,β-Unsaturated Carbonyl Compounds. Intermediates in the Fluoride catalyzed reactions of Silanes
Papers	"Reaction of Metalated Nitriles with Enones," Hans J. Reich,* Margaret M. Biddle and Robert J. Edmonston J. Org. Chem. 2005, 70, 3375-3382. (Full Paper) PDF Suppl. "Studies on the Reactive Species in Fluoride-Mediated Carbon-Carbon Bond-Forming Reactions: Carbanion Formation by Desilylation with Fluoride and Enolates,"Margaret M. Biddle and Hans J. Reich,* J. Org. Chem. 2006, 71, 4031-4039. (Full Paper) PDF Suppl. "Solution Structures of Lithium Enolates of Cyclopentanone, Cyclohexanone, Acetophenones, and Benzyl Ketones. Triple Ions and Higher Lithiate Complexes," Kristopher J. Kolonko, Margaret M. Biddle, Ilia A. Guzei, Hans J. Reich J. Am. Chem. Soc. 2009, 131, 11525-11536 (Article) PDF, Suppl, DOI
Current Position	Medicinal chemist at Astellas Pharmaceuticals, Skokie, Illinois