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Total synthesis of Camptothecin:
Reference: Comins, D. L.; Hong, H.; Jianhua, G. Tetrahedron Lett. 1994, 35, 5331. DOI
Keywords: Aldehyde -> Alkyl-OH • Lactone-6 • Li/H -> Li-Pyridyl • Li/I -> Li-Pyridyl • Li/H -> Li-Quinoline • Radical cyclization(Acyl) • Li-Aryl+Formamide • Li-Aryl+Ketone • Li-Aryl+Aldehyde • EC-Ketone/CarboxEster+Li-R • Hydrogenolysis C-Cl • Mitsunobu -> Amine • Benzyl-OH -> Benzyl-NR2
Reagents: BuLi(n) • DMF (react) • BuLi(n) • I2 • BH4-Na+ • Pyridyl-Li • BuLi(n) • BF3·OEt2 • HCl • H2, Pd • LiNiPr2 • Formaldehyde • PPh3, DEAD • HSnBu3 • AIBN • Pyridyl-Li •

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