image

Total synthesis of Acitretin:
Reference: Andriamialisoa, Z.; Valla, A.; Cartier, D.; Labia, R. Helv. Chim. Acta 2002, 85, 2926. DOI
Keywords: Aldehyde -> Acetal(Me) • Acetal -> Enal • CarboxEster -> CarboxAcid • Claisen acylation, formate • Enone enolate+Formate • Stobbe condensation • Wittig-methyl -> Diene • Decarboxylation •
Reagents: NaOMe • Formate, methyl • H2SO4 • KOtBu • Ph3P=CH2 • Formic acid • Triton B • NEt3 • Hydroxide, sodium • Pyridine •

Syntheses Home