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Total synthesis of Dihydroiso-Codeine:
Reference: Parker, K. A.; Fokas, D. J. Am. Chem. Soc. 1992, 114, 9688
Keywords: N-H -> N-SO2R • Luche reduction • Enone -> Allyl-OH • N-H -> N-Me • Epoxide -> Allyl-OH • O-H -> O-SiMe2tBu • Mitsunobu -> Ether • Alkyl-OH -> Alkyl-OR(2°) • Ether-5 • O-SiMe2tBu -> O-H • Alkyl-OH -> Ketone-α-OR • Radical cyclization(Aryl) • ConjAdd Amine • Amine-6 • Birch reduction • Epoxidation, peracid • Henbest •
Reagents: Li°/NH3 • TsCl, NEt3 • BH4-Na+, CeCl3 • Carbonate, potassium • Perbenzoic acid, 3-chloro • Ti(OiPr)4 • SiMe2tBu-OTf • PBu3, DEAD • HSnBu3 • AIBN • HF • Li° • DMSO, (COCl)2

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